Cassie

Cassie is a major protagonists in the series

Character
Cassie is one of the OMG party cheerleader type of girl, and Avery is her crush. Due to her maturing over the later seasons she stopped developing a crush on Avery and now hangs with Stella.

Avery
Her former crush until Stella came into the show, she now sees him immature with Ash.

Meggy
Despite her hating on Meggy, They are actually friends after what happened to Clover

Ash
Ash and her only interacted once, that was when she mentioned that Ash moved to her old house in Avery's Apartment Building.

Clover
They never appeared in the same episode together except for later seasons.

Friends

 * Meggy
 * Stella
 * Todd
 * Avery
 * Blah Blah Boy

Frenemies
None except for Sierra, Meggy and Clover

Enemies

 * Sierra
 * Meggy (Formerly)
 * Clover